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HDXBoxeR  

Analysis of Hydrogen-Deuterium Exchange Mass-Spectrometry Data
View on CRAN: Click here


Download and install HDXBoxeR package within the R console
Install from CRAN:
install.packages("HDXBoxeR")

Install from Github:
library("remotes")
install_github("cran/HDXBoxeR")

Install by package version:
library("remotes")
install_version("HDXBoxeR", "0.0.1")



Attach the package and use:
library("HDXBoxeR")
Maintained by
Maria K. Janowska
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2024-04-10
Latest Update: 2024-04-10
Description:
A protocol that facilitates the processing and analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data using p-value statistics and Critical Interval analysis. It provides a pipeline for analyzing data from 'HDXExaminer' (Sierra Analytics, Trajan Scientific), automating matching and comparison of protein states through Welch's T-test and the Critical Interval statistical framework. Additionally, it simplifies data export, generates 'Pymol' scripts, and ensures calculations meet publication standards. 'HDXBoxeR' assists in various aspects of hydrogen-deuterium exchange data analysis, including reprocessing data, calculating parameters, identifying significant peptides, generating plots, and facilitating comparison between protein states. For details check papers by Hageman and Weis (2019) <doi:10.1021/acs.analchem.9b01325> and Masson et al. (2019) <doi:10.1038/s41592-019-0459-y>.
How to cite:
Maria K. Janowska (2024). HDXBoxeR: Analysis of Hydrogen-Deuterium Exchange Mass-Spectrometry Data. R package version 0.0.1, https://cran.r-project.org/web/packages/HDXBoxeR
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