R: Objective function for D-optimal OED with detection limit

criterium_D_iso

R Documentation

Objective function for D-optimal OED with detection limit

Points outside of the allowable area are moved back in time to the detection limit

criterium_D_iso(x, model, pars, limit)

`x`	a numeric vector of length `n` defining the design matrix. The first n/2 elements are the time points and the last n/2 are the temperatures of these points.
`model`	character string defining the inactivation model to use.
`pars`	list defining the model parameters according to the rules defined in the bioinactivation package.
`limit`	numerical value describing the maximum number of log-reductions that can be identified in the experiment limit = logDL - logN0, where DL is the detection limit.

Numeric value of the objective function for criterium D, which is a determinant of the FIM.